Sixteen people in Galway died from COVID-19 in the second week of January, the latest CSO report shows.
Over one third of all COVID deaths in the county occurred between 8 January and 15 January, with the death toll rising from 25 to 41 in just seven days.
Across the country, 247 people died due to COVID-19 in the week ending 15 January.
The latest report also shows that than 50 people died due to COVID-19 in each of the three weeks up to the middle of this month.
For the week ending 15 January, the number of weekly cases was 16,461, a decrease of 13,135 from the previous week.
This was the third highest weekly number of cases since the beginning of the pandemic.
The median age of new confirmed cases was 42 years old for the week ending 15 January.
Galway has the lowest median age at 31 while Wicklow is highest at 42, while the overall median age of cases is 38.